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Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode

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dc.contributor.author Dondo, Nyaradzai
dc.contributor.author Shumba, Munyaradzi
dc.contributor.author Moyo, Mambo
dc.contributor.author Nyoni, Stephen
dc.date.accessioned 2021-05-10T13:30:37Z
dc.date.available 2021-05-10T13:30:37Z
dc.date.issued 2020
dc.identifier.issn 18785352
dc.identifier.uri https://reader.elsevier.com/reader/sd/pii/S1878535220303361?token=922EBFACA5205B619B9E717D7E73F638BE5B9D5F1E7C11B43507C80B8777B17565569008A6DDDB0C7EC69D81417F548B&originRegion=eu-west-1&originCreation=20210510085333
dc.identifier.uri http://hdl.handle.net/11408/4153
dc.description.abstract Nitrogen doped carbon nanodots (NDCNDs) and nanosized cobalt tetra aminophenoxy phthalocyanines (CoTAPhPcNPs) modified glassy carbon electrodes have been successfully used in the simultaneous detection of aspirin (ASA), ibuprofen (IBU) and indomethacin (INDO). Scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to probe the nature of the synthesized nanomaterials. Sequential deposition of the nanomaterials on the glassy carbon electrode yielded CoTAPhPcNPs-NDCNDs-GCE with remarkable electrocatalytic performance. Electro-oxidation of the drugs at the electrode surface was first order. This work demonstrates the synergic effect of the two nanomaterials towards simultaneous electrocatalytic detection of the drugs. Superior detection limits of ASA, IBU and INDO being 9.66 10 9 M, 4.19 10 9 M and 7.2 10 9 M, respectively, were obtained using differential pulse voltammetry. The developed sensor could detect two of the three (ibuprofen and indomethacin) simultaneously at significantly different potentials and exhibited remarkable reproducibility after a regeneration step. en_US
dc.language.iso en en_US
dc.publisher Elsevier B.V. en_US
dc.relation.ispartofseries Arabian Journal of Chemistry, Vol. 13: p. 7809-7819;
dc.subject Nanosized cobalt tetra aminophenoxy phthalocyanine en_US
dc.subject Carbon nanodots en_US
dc.subject Electro-detection en_US
dc.title Simultaneous non-steroidal anti-inflammatory drug electrodetection on nitrogen doped carbon nanodots and nanosized cobalt phthallocyanine conjugate modified glassy carbon electrode en_US
dc.type Article en_US


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