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Photophysicochemical behaviour of phenoxy propanoic acid functionalised zinc phthalocyanines when grafted onto iron oxide and silica nanoparticles: Effects in photodynamic antimicrobial chemotherapy

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dc.contributor.author Dube, Edith
dc.contributor.author Soy, Rodah
dc.contributor.author Shumba, Munyaradzi
dc.contributor.author Nyokong, Tebello
dc.date.accessioned 2021-05-05T10:14:59Z
dc.date.available 2021-05-05T10:14:59Z
dc.date.issued 2021-06
dc.identifier.issn 222313
dc.identifier.uri https://www.sciencedirect.com/science/article/abs/pii/S0022231321000557
dc.identifier.uri http://hdl.handle.net/11408/4104
dc.description.abstract This work reports on the covalent linkage of (3-aminopropyl)triethoxysilane (APTES) functionalised iron oxide (IONPs–APTES) and silica (SiNPs–APTES) nanoparticles with zinc(II) tetra–([3–(4–phenoxy) propanoic acid) phthalocyanine] (1) and zinc(II) mono–([3–(4–phenoxy) propanoic acid) phthalocyanine (2) via an amide bond to form the conjugates, 1–IONPs-APTES, 1–SiNPs–APTES, 2-IONPs-APTES and 2-SiNPs-APTES). The photophysicochemical behaviour of the conjugates was investigated. These were characterized by a decrease in the fluorescence quantum yields and lifetimes, and an increase in the triplet quantum yield and singlet oxygen quantum yield when compared to complex 1 and 2 alone. The conjugates to IONPs-APTES displayed higher ΦT than those of SiNPs-APTES probably due to the heavy atom effect of iron compared to silica and the high loading capacity of the relatively smaller iron oxide NPs, however, there was no significant difference in the ΦΔ values of 2-IONPs-APTES (ΦΔ=0.59) and 2-SiNPs-APTES (ΦΔ=0.58), suggesting that the energy transfer process between the excited triplet state of 2-IONPs-APTES and ground state molecular oxygen was not effective. Photodynamic antimicrobial chemotherapy (PACT) studies showed that linkage of Pcs to NPs improves their photoinactivation capability against Staphylococcus aureus and Escherichia coli. IONPs-APTES and its conjugates generally displayed the highest log reductions than SiNPs-APTES and its conjugates except for studies after 75 min of irradiation for S. Aureus where the log reductions are the same. 2-IONP-APTES was recovered using a magnet after each photodegradation cycle and its stability after 3 cycles confirmed re-usability. en_US
dc.language.iso en en_US
dc.publisher Journal of Luminescence en_US
dc.relation.ispartofseries Volume 234;
dc.subject Zinc phthalocyanine en_US
dc.subject Ironoxide en_US
dc.subject Nanoparticles en_US
dc.subject Phenoxy propanoic acid en_US
dc.title Photophysicochemical behaviour of phenoxy propanoic acid functionalised zinc phthalocyanines when grafted onto iron oxide and silica nanoparticles: Effects in photodynamic antimicrobial chemotherapy en_US
dc.type Article en_US


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